Zygolide (pergolide tablets) is a prescription oral medication used to help control the clinical signs associated with Pituitary Pars Intermedia Dysfunction (PPID), commonly known as equine Cushings disease, in horses.
Zygolide contains pergolide, a dopamine receptor agonist that helps support the management of PPID-related symptoms when used as directed by a veterinarian. It is the first FDA-approved generic pergolide product for equine use.
Available by prescription only, Zygolide is administered orally once daily as part of a veterinarian-directed treatment plan tailored to the individual horse.
Administration
Zygolide tablets are administered orally once daily. Dosage should be adjusted to effect under veterinary supervision and should not exceed 4 mcg/kg of body weight per day.
Tablets are scored to allow accurate dosing. The calculated dose should be rounded to the nearest one-half tablet increment when necessary.
Important Handling Information
Pergolide tablets may cause eye irritation, headache, or an unpleasant odor if split or crushed.
Zygolide tablets should not be crushed due to the potential for increased human exposure.
When splitting tablets, care should be taken to minimize direct handling and exposure.
Wash hands after handling tablets or tablet fragments.
Directions
Warnings
Important: Do not use in horses intended for human consumption.
Keep Zygolide in a secure location out of reach of dogs, cats, and other animals.
Accidental ingestion or overdose may result in adverse reactions.
Dogs have been reported to ingest pergolide tablets that were mixed with horse feed or dropped during administration.
Adverse reactions may occur if Zygolide tablets are ingested by animals other than horses.
Carefully collect and dispose of any dropped or unused tablet fragments.
Precautions
Treatment with Zygolide may cause decreased appetite (inappetence).
The safety of Zygolide in breeding, pregnant, or lactating horses has not been evaluated.
The effects of pergolide mesylate in these populations are currently unknown.
Due to its pharmacologic activity, pergolide may interfere with reproductive functions, including lactation.
Veterinary Guidance Recommended: Discuss the risks and benefits of treatment with your veterinarian before administering Zygolide to breeding, pregnant, or nursing mares.
